In Vorbereitung.

Ausgewählte Publikationen:

Heneka MT, Landreth GE, Hull M Drug insight: Peroxisome proliferator-activated receptor γ in CNS disorders (2007) Nat. Rev. Neurol. 3: 496-504.

Heneka MT, Nadrigny F, Regen T, Dumitrescu-Ozimek L, Terwel D, Jardanhazi-Kurutz D, Walter J, Kirchhoff F, Hanisch U, Kummer MP (2010) Locus ceruleus controls Alzheimer disease pathology by modulating microglial functions through norepinephrine. Proc. Natl. Acad. Sci. U.S.A., 107:6058-63.

Heneka MT, Sastre M, Dumitrescu-Ozimek L, Hanke A, Dewachter I, Cuiperi K, O´Banion MK, Klockgether T, Van Leuven F, Landreth GE (2005) Acute treatment with the PPARg agonist pioglitazone and ibuprofen reduces inflammation and Ab1-42 levels in APP V717I transgenic mice. Brain 128: 1442-1453.

Schütz B, Reimann J, Dumitrescu-Ozimek L, Kappes-Horn K, Landreth GE, Schürmann B, Zimmer A, Heneka MT (2005) The oral antidiabetic pioglitazone protects from neurodegeneration and ALS-like symptoms in SOD1-G93A transgenic mice. J. Neurosci. 25: 7805-7812.

Sastre M, Dewachter I, Roßner S, Bogdanovic N, Rosen E, Borghgraef P, Evert BO, Dumitrescu-Ozimek L, Thal DR, Landreth G, Walter J, Klockgether T, Van Leuven F, Heneka MT (2006) NSAIDs repress BACE1 gene promoter activity by the activation of PPARg. Proc. Natl. Acad. Sci. U.S.A. 103:443-448.

Sastre M, Dewachter I, Landreth GE, Willson TM, Klockgether T, Van Leuven F, Heneka MT (2003) Nonsteroidal anti-Inflammatory drugs and peroxisome proliferator-activated receptor-g agonists modulate immunostimulated processing of amyloid precursor protein through regulation of b-Secretase. J. Neurosci. 23: 9796-9804.

Terwel D, Steffensen KR, Verghese PB, Kummer MP, Gustafsson JÅ, Holtzman DM, Heneka MT. Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis. J Neurosci. 2011 May 11;31(19):7049-59.

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