Cerebral microangiopathy (also called cerebral small-vessel disease) is an increasingly common diagnosis in the elderly and can be the result of a wide range of diseases, including diabetes mellitus. Advances in brain imaging methods have enabled researchers to relate two types of lesions found in this disease: leukoaraiosis and lacunar infarcts.

The clinical picture often manifests itself in patients in gait disturbance, incontinence, dementia and depression. It has been shown that the pathogenesis is favored by vascular risk factors, the most important are age and hypertension. The relative risk of other factors such as obesity, diabetes, hypercholesterolemia, smoking and alcohol has been less explored. Recent studies have now turned their interest to see if progression of cerebral microangiopathy can be reduced by the treatment of vascular risk factors.

Our research is aimed at elucidating the clinical picture of these patients and better understand the pathogenesis, with the goal of offering more effective treatments.


Okroglic, S., Widmann, C., Urbach, H., Scheltens, P. & Heneka, M. T. (2013). Clinical symptoms, risk factors and cardiovascular medication in cerebral microangiopathy patients. PLOS One. 8(2):e53455 [Mehr] [Bibtex] [RIS] [MODS]