2012

Kummer, MP, Hülsmann, C, Hermes, M, Axt, D and Heneka, MT
NOS2 derived nitric oxide decreases the enzymatic activity of insulin degrading enzyme in APP/PS1 mice
J Neuroimmune Pharmacol., in press

2011

Kummer, Markus P., Hermes, Michael, Delekate, Andrea, Hammerschmidt, Thea, Kumar, Sathish, Terwel, Dick, Walter, Jochen, Pape, Hans-Christian, König, Simone, Roeber, Sigrun, Jessen, Frank, Klockgether, Thomas, Korte, Martin and Heneka, Michael T.
Nitration of tyrosine 10 critically enhances amyloid β aggregation and plaque formation.
Neuron. 2011 Sep 8;71(5):833-44.

Mildner A, Schlevogt B, Kierdorf K, Böttcher C, Erny D, Kummer MP, Quinn M, Brück W, Bechmann I, Heneka MT, Priller J, Prinz M.
Distinct and Non-Redundant Roles of Microglia and Myeloid Subsets in Mouse Models of Alzheimer's Disease.
J Neurosci. 2011 Aug 3;31(31):11159-11171. PMID: 21813677

Mattsson N, Andreasson U, Persson S, Arai H, Batish SD, Bernardini S, Bocchio-Chiavetto L, Blankenstein MA, Carrillo MC, Chalbot S, Coart E, Chiasserini D, Cutler N, Dahlfors G, Duller S, Fagan AM, Forlenza O, Frisoni GB, Galasko D, Galimberti D, Hampel H, Handberg A, Heneka MT, Herskovits AZ, Herukka SK, Holtzman DM, Humpel C, Hyman BT, Iqbal K, Jucker M, Kaeser SA, Kaiser E, Kapaki E, Kidd D, Klivenyi P, Knudsen CS, Kummer MP, Lui J, Lladó A, Lewczuk P, Li QX, Martins R, Masters C, McAuliffe J, Mercken M, Moghekar A, Molinuevo JL, Montine TJ, Nowatzke W, O'Brien R, Otto M, Paraskevas GP, Parnetti L, Petersen RC, Prvulovic D, de Reus HP, Rissman RA, Scarpini E, Stefani A, Soininen H, Schröder J, Shaw LM, Skinningsrud A, Skrogstad B, Spreer A, Talib L, Teunissen C, Trojanowski JQ, Tumani H, Umek RM, Van Broeck B, Vanderstichele H, Vecsei L, Verbeek MM, Windisch M, Zhang J, Zetterberg H, Blennow K.
The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers.
Alzheimers Dement. 2011 Jul;7(4):386-395.e6. PMID: 21784349

Microglial activation in a neuroinflammational animal model of schizophrenia - a pilot study.
Juckel G, Manitz MP, Brüne M, Friebe A, Heneka MT, Wolf RJ.
Schizophr Res. 2011 Sep;131(1-3):96-100. Epub 2011 Jul 12. PMID: 21752601

Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis.
Terwel D, Steffensen KR, Verghese PB, Kummer MP, Gustafsson JÅ, Holtzman DM, Heneka MT.
J Neurosci. 2011 May 11;31(19):7049-59. PMID: 21562267

Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease.
Kumar S, Rezaei-Ghaleh N, Terwel D, Thal DR, Richard M, Hoch M, Mc Donald JM, Wüllner U, Glebov K, Heneka MT, Walsh DM, Zweckstetter M, Walter J.
EMBO J. 2011 Jun 1;30(11):2255-65. Epub 2011 Apr 28. PMID: 21527912

Neuroinflammatory and behavioural changes in the Atp7B mutant mouse model of Wilson's disease.
Terwel D, Löschmann YN, Schmidt HH, Schöler HR, Cantz T, Heneka MT.
J Neurochem. 2011 Jul;118(1):105-12. PMID: 21517843

Molecular mechanisms and therapeutic application of NSAIDs and derived compounds in Alzheimer's disease.
Heneka MT, Kummer MP, Weggen S, Bulic B, Multhaup G, Münter L, Hüll M, Pflanzner T, Pietrzik CU.
Curr Alzheimer Res. 2011 Mar;8(2):115-31. PMID:21345168

Distinct adrenergic system changes and neuroinflammation in response to induced locus ceruleus degeneration in APP/PS1 transgenic mice.
Jardanhazi-Kurutz D, Kummer MP, Terwel D, Vogel K, Thiele A, Heneka MT.
Neuroscience. 2011 Mar 10;176:396-407. Epub 2010 Dec 1. PMID: 21129451

2010

Locus coeruleus degeneration exacerbates olfactory deficits in APP/PS1 transgenic mice.
Rey NL, Jardanhazi-Kurutz D, Terwel D, Kummer MP, Jourdan F, Didier A, Heneka MT.
Neurobiol Aging. 2010 Nov 23. [Epub ahead of print]PMID: 21109328

Restraint stress increases neuroinflammation independently of Aβ levels in APP/PS1 transgenic mice.
Perez Nievas BG, Hammerschmidt T, Kummer MP, Terwel D, Leza JC, Heneka MT.
J Neurochem. 2010 Oct 29.

Distinct modulation of microglial amyloid β phagocytosis and migration by neuropeptides
Fleisher-Berkovich S, Filipovich-Rimon T, Ben-Shmuel S, Hülsmann C, Kummer MP, Heneka MT.
J Neuroinflammation. 2010 Oct 11;7:61.

Statins promote the degradation of extracellular amyloid β-peptide by microglia via stimulation of exosome-associated IDE secretion.
Tamboli IY, Barth E, Christian L, Siepmann M, Singh S, Tolksdorf K, Heneka MT, Luetjohann D, Wunderlich P, Walter J.
J. Biol. Chem. 2010 Sep 28.

Neuroinflammatory processes in Alzheimer's disease.
Heneka MT, O'Banion MK, Terwel D, Kummer MP.
J. Neural Transm. 2010 Aug;117(8):919-47. Epub 2010 Jul 15

Everyday memory deficits in very mild Alzheimer's disease.
Widmann CN, Beinhoff U, Riepe MW
Neurobiol Aging. 2010 Apr 12.

Locus ceruleus controls Alzheimer disease pathology by modulating microglial functions through norepinephrine
Heneka MT, Nadrigny F, Regen F, Martinez-Hernandez A, Dumitrescu-Ozimek L, Terwel D, Jardanhazi-Kurutz D, Walter J, Kirchhoff F, Hanisch UK and Kummer MP
Proc Natl Acad Sci U S A. 2010

Jardanhazi-Kurutz D, Kummer MP, Terwel D, Vogel K, Dyrks T, Thiele A, Heneka MT.
Induced LC degeneration in APP/PS1 transgenic mice accelerates early cerebral amyloidosis and cognitive deficits.
Neurochem. Int. 2010 Feb 6.

Norepinephrine enhances the LPS-induced expression of COX-2 and secretion of PGE2 in primary rat microglia.
Schlachetzki JC, Fiebich BL, Haake E, de Oliveira AC, Candelario-Jali E, Heneka MT, Hull M.
J Neuroinflammation. 2010 Jan 11;7(1):2.

2009

Neuroglia in neurodegeneration.
Heneka MT, Rodríguez JJ, Verkhratsky A.
Brain Res Rev. 2009 Nov 26.

Weberpals M, Hermes M, Hermann S, Kummer MP, Terwel D, Semmler A, Berger M, Schäfers M, Heneka MT
NOS2 gene deficiency protects from sepsis-induced long-term cognitive deficits
J Neurosci. 2009 Nov 11;29(45):14177-84.

α-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Abeta generation.
Jäger S, Leuchtenberger S, Martin A, Czirr E, Wesselowski J, Dieckmann M, Waldron E, Korth C, Koo EH, Heneka M, Weggen S, Pietrzik CU
J Neurochem. 2009 Dec;111(6):1369-82.

Papi A, Tatenhorst L, Terwel D, Hermes M, Kummer MP, Orlandi M, Heneka MT.
PPARγ and RXRγ ligands act synergistically as potent antineoplastic agents in vitro and in vivo glioma models
J. Neurochem. 2009, May 11

Heneka MT
Noradrenergic denervation facilitates the release of acetylcholine and serotonin in the hippocampus: Towards a mechanism underlying upregulations described in MCI patients.
Exp Neurol. 2009 Mar 25.
PMID: 19328200

Kummer MP, Maruyama H, Huelsmann C, Baches S, Weggen S, Koo EH.
Formation of PMEL17 amyloid is regulated by juxtamembrane metalloproteinase cleavage and the resulting C-terminal fragment is a substrate for gamma-secretase.
J Biol Chem. 2008 Jan 23;284(4):2296-306.
PMID: 19047044

2008

Tamboli IY, Prager K, Thal DR, Thelen KM, Dewachter I, Pietrzik CU, St George-Hyslop P, Sisodia SS, De Strooper B, Heneka MT, Filippov MA, Müller U, van Leuven F, Lütjohann D, Walter J.
Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis.
J Neurosci. 2008 Nov 12;28(46):12097-106.
PMID: 1900507

Seufert S, Coras R, Tränkle C, Zlotos DP, Blümcke I, Tatenhorst L, Heneka MT, Hahnen E.
PPAR Gamma Activators: Off-Target Against Glioma Cell Migration and Brain Invasion.
PPAR Res. 2008;2008:513943.
PMID: 18815619

Semmler A, Hermann S, Mormann F, Weberpals M, Paxian SA, Okulla T, Schäfers M, Kummer MP, Klockgether T, Heneka MT.
Sepsis causes neuroinflammation and concomitant decrease of cerebral metabolism.
J Neuroinflammation. 2008 Sep 15;5:38.
PMID: 18793399

Tatenhorst L, Hahnen E, Heneka MT.
Peroxisome Proliferator-Activated Receptors (PPARs) as Potential Inducers of Antineoplastic Effects in CNS Tumors.
PPAR Res. 2008;2008:204514.
PMID: 18725982

Kummer MP, Heneka MT.
PPARs in Alzheimer's Disease.
PPAR Res. 2008;2008:403896. PMID: 18645613

Winkeler A, Waerzeggers Y, Klose A, Monfared P, Thomas AV, Schubert M, Heneka MT, Jacobs AH.

Imaging noradrenergic influence on amyloid pathology in mouse models of Alzheimer's disease.
Eur J Nucl Med Mol Imaging. 2008 Mar;35 Suppl 1:S107-13.  PMID: 18219484

2007

Thees C, Kaiser M, Scholz M, Semmler A, Heneka MT, Baumgarten G, Hoeft A, Putensen C.
Cerebral haemodynamics and carbon dioxide reactivity during sepsis syndrome.
Crit Care. 2007;11(6):R123. PMID: 18045492

Heneka MT, Landreth GE, Hüll M.
Drug insight: effects mediated by peroxisome proliferator-activated receptor-gamma in CNS disorders.
Nat Clin Pract Neurol. 2007 Sep;3(9):496-504. PMID: 17805244
Heneka MT, Landreth GE.

PPARs in the brain.
Biochim Biophys Acta. 2007 Aug;1771(8):1031-45. Epub 2007 May 10. PMID: 17569578

Kummer C, Winkeler A, Dittmar C, Bauer B, Rueger MA, Rueckriem B, Heneka MT, Vollmar S, Wienhard K, Fraefel C, Heiss WD, Jacobs AH.
Multitracer positron emission tomographic imaging of exogenous gene expression
mediated by a universal herpes simplex virus 1 amplicon vector.
Mol Imaging. 2007 May-Jun;6(3):181-92. PMID: 17532884

Rueger MA, Kracht LW, Hilker R, Thiel A, Sobesky J, Winkeler A, Thomas AV, Heneka MT, Graf R, Herholz K, Heiss WD, Jacobs AH.
Role of in vivo imaging of the central nervous system for developing novel drugs.
Q J Nucl Med Mol Imaging. 2007 Jun;51(2):164-81. PMID: 17420717

Jacobs AH, Rueger MA, Winkeler A, Li H, Vollmar S, Waerzeggers Y, Rueckriem B, Kummer C, Dittmar C, Klein M, Heneka MT, Herrlinger U, Fraefel C, Graf R, Wienhard K, Heiss WD.
Imaging-guided gene therapy of experimental gliomas.
Cancer Res. 2007 Feb 15;67(4):1706-15. PMID: 17308112

Semmler A, Frisch C, Debeir T, Ramanathan M, Okulla T, Klockgether T, Heneka MT.
Long-term cognitive impairment, neuronal loss and reduced cortical cholinergic nnervation after recovery from sepsis in a rodent model.
Exp Neurol. 2007 Apr;204(2):733-40. Epub 2007 Jan 13. PMID: 17306796

Heneka MT, O'Banion MK.
Inflammatory processes in Alzheimer's disease.
J Neuroimmunol. 2007 Mar;184(1-2):69-91. Epub 2007 Jan 12. PMID: 17222916

Wahle T, Thal DR, Sastre M, Rentmeister A, Bogdanovic N, Famulok M, Heneka MT, Walter J.
GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide.
J Neurosci. 2006 Dec 6;26(49):12838-46. PMID: 17151287

Grommes C, Landreth GE, Sastre M, Beck M, Feinstein DL, Jacobs AH, Schlegel, Heneka MT.
Inhibition of in vivo glioma growth and invasion by peroxisome proliferator-activated receptor gamma agonist treatment.
Mol Pharmacol. 2006 Nov;70(5):1524-33. PMID: 16887936

Ambrée O, Leimer U, Herring A, Görtz N, Sachser N, Heneka MT, Paulus W, Keyvani K.
Reduction of amyloid angiopathy and Abeta plaque burden after enriched housing in TgCRND8 mice: involvement of multiple pathways.
Am J Pathol. 2006 Aug;169(2):544-52. PMID: 16877355

Kalinin S, Gavrilyuk V, Polak PE, Vasser R, Zhao J, Heneka MT, Feinstein DL.
Noradrenaline deficiency in brain increases beta-amyloid plaque burden in animal model of Alzheimer's disease.
Neurobiol Aging. 2007 Aug;28(8):1206-14. Epub 2006 Jul 11.
PMID: 16837104

2006

Shaked GM, Kummer MP, Lu DC, Galvan V, Bredesen DE, Koo EH.

Abeta induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597-624).
FASEB J. 2006 Jun;20(8):1254-6. PMID: 16636103

Sastre M, Klockgether T, Heneka MT.
Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms.
Int J Dev Neurosci. 2006 Apr-May;24(2-3):167-76. PMID: 16472958

Heneka MT, Ramanathan M, Jacobs AH, Dumitrescu-Ozimek L, Bilkei-Gorzo A, Debeir T, Sastre M, Galldiks N, Zimmer A, Hoehn M, Heiss WD, Klockgether T, Staufenbiel M.
Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice.
J Neurosci. 2006 Feb 1;26(5):1343-54. PMID: 16452658

Sastre M, Dewachter I, Rossner S, Bogdanovic N, Rosen E, Borghgraef P, Evert BO, Dumitrescu-Ozimek L, Thal DR, Landreth G, Walter J, Klockgether T, van Leuven F, Heneka MT.
Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma.
Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):443-8. PMID: 16407166

Leuchtenberger S, Kummer MP, Kukar T, Czirr E, Teusch N, Sagi SA, Berdeaux R, Pietrzik CU, Ladd TB, Golde TE, Koo EH, Weggen S.
Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42.
J Neurochem. 2006 Jan;96(2):355-65. PMID: 16300630

2005

Heneka MT, Sastre M, Dumitrescu-Ozimek L, Dewachter I, Walter J, Klockgether T, Van Leuven F.
Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice.
J Neuroinflammation. 2005 Oct 7;2:22. PMID: 16212664

Klotz L, Schmidt M, Giese T, Sastre M, Knolle P, Klockgether T, Heneka MT.
Proinflammatory stimulation and pioglitazone treatment regulate peroxisome proliferator-activated receptor gamma levels in peripheral blood mononuclear cells from healthy controls and multiple sclerosis patients.
J Immunol. 2005 Oct 15;175(8):4948-55. PMID: 16210596

Semmler A, Okulla T, Sastre M, Dumitrescu-Ozimek L, Heneka MT.
Systemic inflammation induces apoptosis with variable vulnerability of different brain regions.
J Chem Neuroanat. 2005 Oct;30(2-3):144-57. PMID: 16122904

Schütz B, Reimann J, Dumitrescu-Ozimek L, Kappes-Horn K, Landreth GE,
Schürmann B, Zimmer A, Heneka MT.
The oral antidiabetic pioglitazone protects from neurodegeneration and
amyotrophic lateral sclerosis-like symptoms in superoxide dismutase-G93A
transgenic mice.
J Neurosci. 2005 Aug 24;25(34):7805-12.
PMID: 16120782 [PubMed - indexed for MEDLINE]

Heneka MT, Sastre M, Dumitrescu-Ozimek L, Hanke A, Dewachter I, Kuiperi C, O'Banion K, Klockgether T, Van Leuven F, Landreth GE.
Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces lial inflammation and Abeta1-42 levels in APPV717I transgenic mice.
Brain. 2005 Jun;128(Pt 6):1442-53. Epub 2005 Apr 7. PMID: 15817521

Rueger MA, Winkeler A, Miletic H, Kaestle C, Richter R, Schneider G, Hilker R, Heneka MT, Ernestus RI, Hampl JA, Fraefel C, Jacobs AH.
Variability in infectivity of primary cell cultures of human brain tumors with HSV-1 amplicon vectors.
Gene Ther. 2005 Apr;12(7):588-96. PMID: 15674397

Grommes C, Landreth GE, Schlegel U, Heneka MT.
The nonthiazolidinedione tyrosine-based peroxisome proliferator-activated receptor gamma ligand GW7845 induces apoptosis and limits migration and invasion of rat and human glioma cells.
J Pharmacol Exp Ther. 2005 May;313(2):806-13. PMID: 15665144

2004

Lacombe P, Mathews PM, Schmidt SD, Breidert T, Heneka MT, Landreth GE,
Feinstein DL, Galea E.
Effect of anti-inflammatory agents on transforming growth factor beta
over-expressing mouse brains: a model revised.
J Neuroinflammation. 2004 Jul 2;1(1):11.
PMID: 15285804 [PubMed - as supplied by publisher]

Pershadsingh HA, Heneka MT, Saini R, Amin NM, Broeske DJ, Feinstein DL.
Effect of pioglitazone treatment in a patient with secondary multiple sclerosis.
J Neuroinflammation. 2004 Apr 20;1(1):3.
PMID: 15285799 [PubMed - as supplied by publisher]

Grommes C, Landreth GE, Heneka MT.
Antineoplastic effects of peroxisome proliferator-activated receptor gamma agonists.
Lancet Oncol. 2004 Jul;5(7):419-29. Review.
PMID: 15231248 [PubMed - indexed for MEDLINE]

Schneider SW, Ludwig T, Tatenhorst L, Braune S, Oberleithner H, Senner V, Paulus W.
Glioblastoma cells release factors that disrupt blood-brain barrier features.
Acta Neuropathol. 2004 Mar;107(3):272-6. Epub 2004 Jan 17.
PMID: 14730455 [PubMed - indexed for MEDLINE]

Dehmer T, Heneka MT, Sastre M, Dichgans J, Schulz JB.
Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with I kappa B alpha induction and block of NF kappa B and iNOS activation.
J Neurochem. 2004 Jan;88(2):494-501. PMID: 14690537

Schmitz A, Schneider A, Kummer MP, Herzog V.
Endoplasmic reticulum-localized amyloid beta-peptide is degraded in the cytosol by two distinct degradation pathways.
Traffic. 2004 Feb;5(2):89-101. PMID: 14690498

Schmidt S, Moric E, Schmidt M, Sastre M, Feinstein DL, Heneka MT.
Anti-inflammatory and antiproliferative actions of PPAR-gamma agonists on T
lymphocytes derived from MS patients.
J Leukoc Biol. 2004 Mar;75(3):478-85. Epub 2003 Dec 4.
PMID: 14657213 [PubMed - indexed for MEDLINE]

2003

Pedraza CE, Baltrons MA, Heneka MT, García A.
Interleukin-1 beta and lipopolysaccharide decrease soluble guanylyl cyclase in brain cells: NO-independent destabilization of protein and NO-dependent decrease of mRNA.
J Neuroimmunol. 2003 Nov;144(1-2):80-90. PMID: 14597101

Sastre M, Dewachter I, Landreth GE, Willson TM, Klockgether T, van Leuven F, Heneka MT.
Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase.
J Neurosci. 2003 Oct 29;23(30):9796-804. PMID: 14586007

Galea E, Heneka MT, Dello Russo C, Feinstein DL.
Intrinsic regulation of brain inflammatory responses.
Cell Mol Neurobiol. 2003 Oct;23(4-5):625-35. Review. PMID: 14514020

Klotz L, Sastre M, Kreutz A, Gavrilyuk V, Klockgether T, Feinstein DL, Heneka MT.
Noradrenaline induces expression of peroxisome proliferator activated receptor gamma (PPARgamma) in murine primary astrocytes and neurons.
J Neurochem. 2003 Aug;86(4):907-16. PMID: 12887689

Harzheim M, Altenschmidt M, Heneka MT, Schröder R, Klockgether T, Schmidt S.
IFN-beta1a (Rebif) modifies the expression of microfilament-associated cell-cell contacts in C6 glioma cells.
J Interferon Cytokine Res. 2003 Feb;23(2):83-9. PMID: 12744773

Heneka MT, Gavrilyuk V, Landreth GE, O'Banion MK, Weinberg G, Feinstein DL.
Noradrenergic depletion increases inflammatory responses in brain: effects on IkappaB and HSP70 expression.
J Neurochem. 2003 Apr;85(2):387-98. PMID: 12675915

2002

Feinstein DL, Heneka MT, Gavrilyuk V, Dello Russo C, Weinberg G, Galea E.
Noradrenergic regulation of inflammatory gene expression in brain.
Neurochem Int. 2002 Nov;41(5):357-65. Review. PMID: 12176079

Breidert T, Callebert J, Heneka MT, Landreth G, Launay JM, Hirsch EC.
Protective action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a mouse model of Parkinson's disease.
J Neurochem. 2002 Aug;82(3):615-24. PMID: 12153485

Baltrons MA, Pedraza CE, Heneka MT, García A.
Beta-amyloid peptides decrease soluble guanylyl cyclase expression in astroglial
cells.
Neurobiol Dis. 2002 Jul;10(2):139-49. PMID: 12127152

Feinstein DL, Galea E, Gavrilyuk V, Brosnan CF, Whitacre CC, Dumitrescu-Ozimek L, Landreth GE, Pershadsingh HA, Weinberg G, Heneka MT.
Peroxisome proliferator-activated receptor-gamma agonists prevent experimental autoimmune encephalomyelitis.
Ann Neurol. 2002 Jun;51(6):694-702. PMID: 12112074

Zander T, Kraus JA, Grommes C, Schlegel U, Feinstein D, Klockgether T, Landreth G, Koenigsknecht J, Heneka MT.
Induction of apoptosis in human and rat glioma by agonists of the nuclear
receptor PPARgamma.
J Neurochem. 2002 Jun;81(5):1052-60. PMID: 12065618

Gavrilyuk V, Dello Russo C, Heneka MT, Pelligrino D, Weinberg G, Feinstein DL.
Norepinephrine increases I kappa B alpha expression in astrocytes.
J Biol Chem. 2002 Aug 16;277(33):29662-8. PMID: 12050158

Heneka MT, Galea E, Gavriluyk V, Dumitrescu-Ozimek L, Daeschner J, O'Banion
MK, Weinberg G, Klockgether T, Feinstein DL.
Noradrenergic depletion potentiates beta -amyloid-induced cortical inflammation:
implications for Alzheimer's disease.
J Neurosci. 2002 Apr 1;22(7):2434-42.
PMID: 11923407 [PubMed - indexed for MEDLINE]

Murphy P, Sharp A, Shin J, Gavrilyuk V, Dello Russo C, Weinberg G, Sharp FR,
Lu A, Heneka MT, Feinstein DL.
Suppressive effects of ansamycins on inducible nitric oxide synthase expression
and the development of experimental autoimmune encephalomyelitis.
J Neurosci Res. 2002 Feb 15;67(4):461-70.
PMID: 11835313 [PubMed - indexed for MEDLINE]

2001

Landreth GE, Heneka MT.
Anti-inflammatory actions of peroxisome proliferator-activated receptor gamma
agonists in Alzheimer's disease.
Neurobiol Aging. 2001 Nov-Dec;22(6):937-44. Review.
PMID: 11755002 [PubMed - indexed for MEDLINE]

Heneka MT, Wiesinger H, Dumitrescu-Ozimek L, Riederer P, Feinstein DL,
Klockgether T.
Neuronal and glial coexpression of argininosuccinate synthetase and inducible
nitric oxide synthase in Alzheimer disease.
J Neuropathol Exp Neurol. 2001 Sep;60(9):906-16.
PMID: 11556547 [PubMed - indexed for MEDLINE]

Heneka MT, Sharp A, Murphy P, Lyons JA, Dumitrescu L, Feinstein DL.
The heat shock response reduces myelin oligodendrocyte glycoprotein-induced
experimental autoimmune encephalomyelitis in mice.
J Neurochem. 2001 Apr;77(2):568-79.
PMID: 11299319 [PubMed - indexed for MEDLINE]

Heneka MT, Feinstein DL.
Expression and function of inducible nitric oxide synthase in neurons.
J Neuroimmunol. 2001 Mar 1;114(1-2):8-18. Review.
PMID: 11240010 [PubMed - indexed for MEDLINE]

Heneka MT, Landreth GE, Feinstein DL.
Role for peroxisome proliferator-activated receptor-gamma in Alzheimer's disease.
Ann Neurol. 2001 Feb;49(2):276. No abstract available.
PMID: 11220752 [PubMed - indexed for MEDLINE]

2000

Hoffmann J, Twiesselmann C, Kummer MP, Romagnoli P, Herzog V.
A possible role for the Alzheimer amyloid precursor protein in the regulation of
epidermal basal cell proliferation.
Eur J Cell Biol. 2000 Dec;79(12):905-14.
PMID: 11152291 [PubMed - indexed for MEDLINE]

Hitzel C, Kanzler H, König A, Kummer MP, Brix K, Herzog V, Koch N.
Thyroglobulin type-I-like domains in invariant chain fusion proteins mediate
resistance to cathepsin L digestion.
FEBS Lett. 2000 Nov 17;485(1):67-70.
PMID: 11086167 [PubMed - indexed for MEDLINE]

Heneka MT, Klockgether T, Feinstein DL.
Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal
inducible nitric oxide synthase expression and cell death in vivo.
J Neurosci. 2000 Sep 15;20(18):6862-7. Erratum in: J Neurosci 2000 Nov
15;20(22):1a.
PMID: 10995830 [PubMed - indexed for MEDLINE]

Heneka MT, Sharp A, Klockgether T, Gavrilyuk V, Feinstein DL.
The heat shock response inhibits NF-kappaB activation, nitric oxide synthase type
2 expression, and macrophage/microglial activation in brain.
J Cereb Blood Flow Metab. 2000 May;20(5):800-11.
PMID: 10826530 [PubMed - indexed for MEDLINE]

Heneka MT, Dumitrescu L, Löschmann PA, Wüllner U, Klockgether T.
Temporal, regional, and cell-specific changes of iNOS expression after
intrastriatal microinjection of interferon gamma and bacterial
lipopolysaccharide.
J Chem Neuroanat. 2000 Apr;18(4):167-79.
PMID: 10781735 [PubMed - indexed for MEDLINE]

1999

Heneka MT, Feinstein DL, Galea E, Gleichmann M, Wüllner U, Klockgether T.
Peroxisome proliferator-activated receptor gamma agonists protect cerebellar
granule cells from cytokine-induced apoptotic cell death by inhibition of
inducible nitric oxide synthase.
J Neuroimmunol. 1999 Dec;100(1-2):156-68.
PMID: 10695726 [PubMed - indexed for MEDLINE]

Heneka MT, Schmidlin A, Wiesinger H.
Induction of argininosuccinate synthetase in rat brain glial cells after striatal
microinjection of immunostimulants.
J Cereb Blood Flow Metab. 1999 Aug;19(8):898-907.
PMID: 10458597 [PubMed - indexed for MEDLINE]