2010
Everyday memory deficits in very mild Alzheimer's disease.
Widmann CN, Beinhoff U, Riepe MW
Neurobiol Aging. 2010 Apr 12. [Epub ahead of print]
Locus ceruleus controls Alzheimer disease pathology by modulating microglial functions through norepinephrine
Heneka MT, Nadrigny F, Regen F, Martinez-Hernandez A, Dumitrescu-Ozimek L, Terwel D, Jardanhazi-Kurutz D, Walter J, Kirchhoff F, Hanisch UK and Kummer MP
Proc Natl Acad Sci U S A. 2010, Published online before print March 15, 2010
Jardanhazi-Kurutz D, Kummer MP, Terwel D, Vogel K, Dyrks T, Thiele A, Heneka MT.
Induced LC degeneration in APP/PS1 transgenic mice accelerates early cerebral amyloidosis and cognitive deficits.
Neurochem. Int. 2010 Feb 6. [Epub ahead of print]
Norepinephrine enhances the LPS-induced expression of COX-2 and secretion of PGE2 in primary rat microglia.
Schlachetzki JC, Fiebich BL, Haake E, de Oliveira AC, Candelario-Jali E, Heneka MT, Hull M.
J Neuroinflammation. 2010 Jan 11;7(1):2.
2009
Neuroglia in neurodegeneration.
Heneka MT, Rodríguez JJ, Verkhratsky A.
Brain Res Rev. 2009 Nov 26.
Weberpals M, Hermes M, Hermann S, Kummer MP, Terwel D, Semmler A, Berger M, Schäfers M, Heneka MT
NOS2 gene deficiency protects from sepsis-induced long-term cognitive deficits
J Neurosci. 2009 Nov 11;29(45):14177-84.
alpha-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Abeta generation.
Jäger S, Leuchtenberger S, Martin A, Czirr E, Wesselowski J, Dieckmann M, Waldron E, Korth C, Koo EH, Heneka M, Weggen S, Pietrzik CU
J Neurochem. 2009 Dec;111(6):1369-82.
Papi A, Tatenhorst L, Terwel D, Hermes M, Kummer MP, Orlandi M, Heneka MT.
PPARγ and RXRγ ligands act synergistically as potent antineoplastic agents in vitro and in vivo glioma models
J. Neurochem. 2009, May 11
Heneka MT
Noradrenergic denervation facilitates the release of acetylcholine and serotonin in the hippocampus: Towards a mechanism underlying upregulations described in MCI patients.
Exp Neurol. 2009 Mar 25.
PMID: 19328200
Kummer MP, Maruyama H, Huelsmann C, Baches S, Weggen S, Koo EH.
Formation of PMEL17 amyloid is regulated by juxtamembrane metalloproteinase cleavage and the resulting C-terminal fragment is a substrate for gamma-secretase.
J Biol Chem. 2008 Jan 23;284(4):2296-306.
PMID: 19047044
2008
Tamboli IY, Prager K, Thal DR, Thelen KM, Dewachter I, Pietrzik CU, St George-Hyslop P, Sisodia SS, De Strooper B, Heneka MT, Filippov MA, Müller U, van Leuven F, Lütjohann D, Walter J.
Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis.
J Neurosci. 2008 Nov 12;28(46):12097-106.
PMID: 1900507
Fischer S, Kleinschnitz C, Müller M, Kobsar I, Ip CW, Rollins BJ, Weishaupt A, Troppmair J, Martini R
Monocyte chemoattractant protein-1 is a pathogenetic component in a model for a hereditary peripheral neuropathy
Mol Cell Neurosci 2008, 37(2): 359-366
Miu J, Mitchell AJ, Müller M, Carter S, , Ball HJ, Lu B, Campbell IL, Hunt, NH
Chemokine gene expression during fatal murine cerebral malaria and protection due to CXCR3 deficiency
J Immunol 2008, 180(2): 1217-1230
Getts DR, Balcar VJ, Matsumoto I, Müller M, King NJ
Viruses and the immune system: their role in seizure cascade development
J Neurochem 2008, 104(5), 1167-1176
Müller M, Wacker K, Ringelstein EB, Kiefer R
Further evidence for a crucial role of resident endoneurial macrophages in peripheral nerve disorders: lessons from acrylamide-induced neuropathy
Glia 2008, 56(9), 1005-1016.
Müller M, Baumeier A, Ringelstein E, Husstedt I. 2008
Long-term tracking of neurological complications of encephalopathy and myopathy in a patient with nephropathic cystinosis: a case report and review of the literature
J Med Case Reports 2008, 2:235.
Getts DR, Terry RL, Getts MT, Müller M, Rana S, Shrestha B, Radford J, Van Rooijen N, Campbell IL, King NJ
Ly6c+ "inflammatory monocytes" are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis
J Exp Med. 2008
PMID: 18779347
Hofer MJ, Carter SL, Müller M, Campbell IL
Unaltered neurological disease and mortality in CXCR3-deficient mice infected intracranially with lymphocytic choriomeningitis virus-Armstrong
Viral Immunol 2008, 21(4):425-33.
Seufert S, Coras R, Tränkle C, Zlotos DP, Blümcke I, Tatenhorst L, Heneka MT, Hahnen E.
PPAR Gamma Activators: Off-Target Against Glioma Cell Migration and Brain Invasion.
PPAR Res. 2008;2008:513943.
PMID: 18815619
Semmler A, Hermann S, Mormann F, Weberpals M, Paxian SA, Okulla T, Schäfers M, Kummer MP, Klockgether T, Heneka MT.
Sepsis causes neuroinflammation and concomitant decrease of cerebral metabolism.
J Neuroinflammation. 2008 Sep 15;5:38.
PMID: 18793399
Tatenhorst L, Hahnen E, Heneka MT.
Peroxisome Proliferator-Activated Receptors (PPARs) as Potential Inducers of Antineoplastic Effects in CNS Tumors.
PPAR Res. 2008;2008:204514.
PMID: 18725982
Kummer MP, Heneka MT.
PPARs in Alzheimer's Disease.
PPAR Res. 2008;2008:403896.
PMID: 18645613
Terwel D, Muyllaert D, Dewachter I, Borghgraef P, Croes S, Devijver H, Van Leuven F.
Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice.
Am J Pathol. 2008 Mar;172(3):786-98. Epub 2008 Feb 7.
PMID: 18258852
Winkeler A, Waerzeggers Y, Klose A, Monfared P, Thomas AV, Schubert M, Heneka MT, Jacobs AH.
Imaging noradrenergic influence on amyloid pathology in mouse models of Alzheimer's disease.
Eur J Nucl Med Mol Imaging. 2008 Mar;35 Suppl 1:S107-13. Review.
PMID: 18219484
Muyllaert D, Terwel D, Kremer A, Sennvik K, Borghgraef P, Devijver H, Dewachter I, Van Leuven F.
Neurodegeneration and neuroinflammation in cdk5/p25-inducible mice: a model for hippocampal sclerosis and neocortical degeneration.
Am J Pathol. 2008 Feb;172(2):470-85. Epub 2008 Jan 17.
PMID: 18202185 [PubMed - indexed for MEDLINE]
2007
Thees C, Kaiser M, Scholz M, Semmler A, Heneka MT, Baumgarten G, Hoeft A, Putensen C.
Cerebral haemodynamics and carbon dioxide reactivity during sepsis syndrome.
Crit Care. 2007;11(6):R123.
PMID: 18045492 [PubMed - indexed for MEDLINE]
Heneka MT, Landreth GE, Hüll M.
Drug insight: effects mediated by peroxisome proliferator-activated
receptor-gamma in CNS disorders.
Nat Clin Pract Neurol. 2007 Sep;3(9):496-504. Review.
PMID: 17805244 [PubMed - indexed for MEDLINE]
Dewachter I, Filipkowski RK, Priller C, Ris L, Neyton J, Croes S, Terwel D,
Gysemans M, Devijver H, Borghgraef P, Godaux E, Kaczmarek L, Herms J, Van Leuven F.
Deregulation of NMDA-receptor function and down-stream signaling in APP[V717I] transgenic mice.
Neurobiol Aging. 2007 Jul 26. [Epub ahead of print]
PMID: 17673336 [PubMed - as supplied by publisher]
Heneka MT, Landreth GE.
PPARs in the brain.
Biochim Biophys Acta. 2007 Aug;1771(8):1031-45. Epub 2007 May 10. Review.
PMID: 17569578 [PubMed - indexed for MEDLINE]
Kummer C, Winkeler A, Dittmar C, Bauer B, Rueger MA, Rueckriem B, Heneka MT,
Vollmar S, Wienhard K, Fraefel C, Heiss WD, Jacobs AH.
Multitracer positron emission tomographic imaging of exogenous gene expression
mediated by a universal herpes simplex virus 1 amplicon vector.
Mol Imaging. 2007 May-Jun;6(3):181-92.
PMID: 17532884 [PubMed - indexed for MEDLINE]
Rueger MA, Kracht LW, Hilker R, Thiel A, Sobesky J, Winkeler A, Thomas AV, Heneka MT, Graf R, Herholz K, Heiss WD, Jacobs AH.
Role of in vivo imaging of the central nervous system for developing novel drugs.
Q J Nucl Med Mol Imaging. 2007 Jun;51(2):164-81. Review.
PMID: 17420717 [PubMed - indexed for MEDLINE]
Sennvik K, Boekhoorn K, Lasrado R, Terwel D, Verhaeghe S, Korr H, Schmitz C, Tomiyama T, Mori H, Krugers H, Joels M, Ramakers GJ, Lucassen PJ, Van Leuven F.
Tau-4R suppresses proliferation and promotes neuronal differentiation in the hippocampus of tau knockin/knockout mice.
FASEB J. 2007 Jul;21(9):2149-61. Epub 2007 Mar 6.
PMID: 17341679 [PubMed - indexed for MEDLINE]
Jacobs AH, Rueger MA, Winkeler A, Li H, Vollmar S, Waerzeggers Y, Rueckriem B, Kummer C, Dittmar C, Klein M, Heneka MT, Herrlinger U, Fraefel C, Graf R, Wienhard K, Heiss WD.
Imaging-guided gene therapy of experimental gliomas.
Cancer Res. 2007 Feb 15;67(4):1706-15.
PMID: 17308112 [PubMed - indexed for MEDLINE]
Semmler A, Frisch C, Debeir T, Ramanathan M, Okulla T, Klockgether T, Heneka MT.
Long-term cognitive impairment, neuronal loss and reduced cortical cholinergic nnervation after recovery from sepsis in a rodent model.
Exp Neurol. 2007 Apr;204(2):733-40. Epub 2007 Jan 13.
PMID: 17306796 [PubMed - indexed for MEDLINE]
Heneka MT, O'Banion MK.
Inflammatory processes in Alzheimer's disease.
J Neuroimmunol. 2007 Mar;184(1-2):69-91. Epub 2007 Jan 12. Review.
PMID: 17222916 [PubMed - indexed for MEDLINE]
Wacher C, Müller M, Hofer MJ, Getts DR, Zabaras R, Ousman SS, Terenzi F, Sen GC, King NJ, Campbell IL (2007)
Coordinated regulation and widespread cellular expression of interferon-stimulated genes (ISG) ISG-49, ISG-54, and ISG-56 in the central nervous system after infection with distinct viruses.
J Virol 81(2): 860-71.
Müller M, Carter S, Hofer MJ, Manders P, Getts DR, Dreykluft A, Lu B, Gerard C, King NJ, Campbell
CXCR3 signaling reduces the severity of experimental autoimmune encephalomyelitis by controlling the parenchymal distribution of effector and regulatory T-cells in the central nervous system
J Immunol 2007, 179(5): 2774-86.
Getts DR, Matsumoto I, Müller M, Teague Getts M, Radford J, Shrestha B, Campbell IL, King NJ
Role of IFN-g in an Experimental Murine Model of West Nile Virus-induced Seizures
J Neurochem 2007, 103(3): 1019-1030
Carter S, Müller M, Campbell IL
Expression of the CXCL9, CXCL10 and CXCL11 genes is dependent on IFN-g but exhibits differential cellular localization in the central nervous system in experimental autoimmune encephalomyelitis and in glial cells in vitro
Glia 2007, 55(16): 1728-1739
Wahle T, Thal DR, Sastre M, Rentmeister A, Bogdanovic N, Famulok M, Heneka MT, Walter J.
GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide.
J Neurosci. 2006 Dec 6;26(49):12838-46.
PMID: 17151287 [PubMed - indexed for MEDLINE]
Muyllaert D, Terwel D, Borghgraef P, Devijver H, Dewachter I, Van Leuven F.
Transgenic mouse models for Alzheimer's disease: the role of GSK-3B in combined amyloid and tau-pathology.
Rev Neurol (Paris). 2006 Oct;162(10):903-7.
PMID: 17028556 [PubMed - indexed for MEDLINE]
Grommes C, Landreth GE, Sastre M, Beck M, Feinstein DL, Jacobs AH, Schlegel, Heneka MT.
Inhibition of in vivo glioma growth and invasion by peroxisome proliferator-activated receptor gamma agonist treatment.
Mol Pharmacol. 2006 Nov;70(5):1524-33. Epub 2006 Aug 3.
PMID: 16887936 [PubMed - indexed for MEDLINE]
Ambrée O, Leimer U, Herring A, Görtz N, Sachser N, Heneka MT, Paulus W, Keyvani K.
Reduction of amyloid angiopathy and Abeta plaque burden after enriched housing in TgCRND8 mice: involvement of multiple pathways.
Am J Pathol. 2006 Aug;169(2):544-52.
PMID: 16877355 [PubMed - indexed for MEDLINE]
Kalinin S, Gavrilyuk V, Polak PE, Vasser R, Zhao J, Heneka MT, Feinstein DL.
Noradrenaline deficiency in brain increases beta-amyloid plaque burden in animal model of Alzheimer's disease.
Neurobiol Aging. 2007 Aug;28(8):1206-14. Epub 2006 Jul 11.
PMID: 16837104
2006
Vandebroek T, Terwel D, Vanhelmont T, Gysemans M, Van Haesendonck C, Engelborghs Y, Winderickx J, Van Leuven F.
Microtubule binding and clustering of human Tau-4R and Tau-P301L proteins isolated from yeast deficient in orthologues of glycogen synthase kinase-3beta or cdk5.
J Biol Chem. 2006 Sep 1;281(35):25388-97. Epub 2006 Jul 3.
PMID: 16818492 [PubMed - indexed for MEDLINE]
Kuhlmann MT, Kirchhof P, Klocke R, Hasib L, Stypmann J, Fabritz L, Stelljes M, Tian W, Zwiener M, Müller M, Kienast J, Breithardt G, Nikol S
G-CSF/SCF reduces inducible arrhythmias in the infarcted heart potentially via increased connexin43 expression and arteriogenesis
J Exp Med 2006, 203(1), 87-97
Müller M, Stenner M, Wacker K, Ringelstein EB, Hickey WF, Kiefer R
Contribution of resident endoneurial macrophages to the local cellular response in experimental autoimmune neuritis
J Neuropathol Exp Neurol, 2006, 65(5): 499-507
Müller M, Berghoff M, Kobsar I, Kiefer R, Martini R
Macrophage colony stimulating factor is a crucial factor for the intrinsic macrophage response in mice heterozygously deficient for the myelin protein P0
Exp Neurol 2006
Shaked GM, Kummer MP, Lu DC, Galvan V, Bredesen DE, Koo EH.
Abeta induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597-624).
FASEB J. 2006 Jun;20(8):1254-6. Epub 2006 Apr 24.
PMID: 16636103 [PubMed - indexed for MEDLINE]
Boekhoorn K, Terwel D, Biemans B, Borghgraef P, Wiegert O, Ramakers GJ, de Vos K, Krugers H, Tomiyama T, Mori H, Joels M, van Leuven F, Lucassen PJ.
Improved long-term potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy.
J Neurosci. 2006 Mar 29;26(13):3514-23.
PMID: 16571759 [PubMed - indexed for MEDLINE]
Sastre M, Klockgether T, Heneka MT.
Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms.
Int J Dev Neurosci. 2006 Apr-May;24(2-3):167-76. Epub 2006 Feb 10. Review.
PMID: 16472958
Heneka MT, Ramanathan M, Jacobs AH, Dumitrescu-Ozimek L, Bilkei-Gorzo A, Debeir T, Sastre M, Galldiks N, Zimmer A, Hoehn M, Heiss WD, Klockgether T, Staufenbiel M.
Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice.
J Neurosci. 2006 Feb 1;26(5):1343-54.
PMID: 16452658 [PubMed - indexed for MEDLINE]
Sastre M, Dewachter I, Rossner S, Bogdanovic N, Rosen E, Borghgraef P, Evert BO, Dumitrescu-Ozimek L, Thal DR, Landreth G, Walter J, Klockgether T, van Leuven F, Heneka MT.
Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma.
Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):443-8. Epub 2006 Jan 3.
PMID: 16407166 [PubMed - indexed for MEDLINE]
Leuchtenberger S, Kummer MP, Kukar T, Czirr E, Teusch N, Sagi SA, Berdeaux R,
Pietrzik CU, Ladd TB, Golde TE, Koo EH, Weggen S.
Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack
selectivity for Abeta42.
J Neurochem. 2006 Jan;96(2):355-65. Epub 2005 Nov 21.
PMID: 16300630 [PubMed - indexed for MEDLINE]
2005
Heneka MT, Sastre M, Dumitrescu-Ozimek L, Dewachter I, Walter J, Klockgether
T, Van Leuven F.
Focal glial activation coincides with increased BACE1 activation and precedes
amyloid plaque deposition in APP[V717I] transgenic mice.
J Neuroinflammation. 2005 Oct 7;2:22.
PMID: 16212664 [PubMed]
Klotz L, Schmidt M, Giese T, Sastre M, Knolle P, Klockgether T, Heneka MT.
Proinflammatory stimulation and pioglitazone treatment regulate peroxisome
proliferator-activated receptor gamma levels in peripheral blood mononuclear
cells from healthy controls and multiple sclerosis patients.
J Immunol. 2005 Oct 15;175(8):4948-55.
PMID: 16210596 [PubMed - indexed for MEDLINE]
Semmler A, Okulla T, Sastre M, Dumitrescu-Ozimek L, Heneka MT.
Systemic inflammation induces apoptosis with variable vulnerability of different
brain regions.
J Chem Neuroanat. 2005 Oct;30(2-3):144-57.
PMID: 16122904 [PubMed - indexed for MEDLINE]
Schütz B, Reimann J, Dumitrescu-Ozimek L, Kappes-Horn K, Landreth GE,
Schürmann B, Zimmer A, Heneka MT.
The oral antidiabetic pioglitazone protects from neurodegeneration and
amyotrophic lateral sclerosis-like symptoms in superoxide dismutase-G93A
transgenic mice.
J Neurosci. 2005 Aug 24;25(34):7805-12.
PMID: 16120782 [PubMed - indexed for MEDLINE]
Vandebroek T, Vanhelmont T, Terwel D, Borghgraef P, Lemaire K, Snauwaert J,
Wera S, Van Leuven F, Winderickx J.
Identification and isolation of a hyperphosphorylated, conformationally changed
intermediate of human protein tau expressed in yeast.
Biochemistry. 2005 Aug 30;44(34):11466-75.
PMID: 16114883 [PubMed - indexed for MEDLINE]
Heneka MT, Sastre M, Dumitrescu-Ozimek L, Hanke A, Dewachter I, Kuiperi C,
O'Banion K, Klockgether T, Van Leuven F, Landreth GE.
Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces
glial inflammation and Abeta1-42 levels in APPV717I transgenic mice.
Brain. 2005 Jun;128(Pt 6):1442-53. Epub 2005 Apr 7.
PMID: 15817521 [PubMed - indexed for MEDLINE]
Rueger MA, Winkeler A, Miletic H, Kaestle C, Richter R, Schneider G, Hilker
R, Heneka MT, Ernestus RI, Hampl JA, Fraefel C, Jacobs AH.
Variability in infectivity of primary cell cultures of human brain tumors with
HSV-1 amplicon vectors.
Gene Ther. 2005 Apr;12(7):588-96.
PMID: 15674397 [PubMed - indexed for MEDLINE]
Grommes C, Landreth GE, Schlegel U, Heneka MT.
The nonthiazolidinedione tyrosine-based peroxisome proliferator-activated
receptor gamma ligand GW7845 induces apoptosis and limits migration and invasion
of rat and human glioma cells.
J Pharmacol Exp Ther. 2005 May;313(2):806-13. Epub 2005 Jan 21.
PMID: 15665144 [PubMed - indexed for MEDLINE]
Berghoff M, Samsam M, Müller M, Kobsar I, Toyka KV, Kiefer R, Maurer M, Martini R
Neuroprotective effect of the immune system in a mouse model of severe dysmyelinating hereditary neuropathy: enhanced axonal degeneration following disruption of the RAG-1 gene
Mol Cell Neurosci 2005, 28:118-127
Schilling M, Besselmann M, Müller M, Strecker JK, Ringelstein EB, Kiefer R
Predominant phagocytic activity of resident microglia over hematogenous macrophages following transient focal cerebral ischemia: An investigation using green fluorescent protein transgenic bone marrow chimeric mice
Exp Neurol 2005, 196(2), 290-297
Terwel D, Lasrado R, Snauwaert J, Vandeweert E, Van Haesendonck C, Borghgraef
P, Van Leuven F.
Changed conformation of mutant Tau-P301L underlies the moribund tauopathy, absent
in progressive, nonlethal axonopathy of Tau-4R/2N transgenic mice.
J Biol Chem. 2005 Feb 4;280(5):3963-73. Epub 2004 Oct 27.
PMID: 15509565 [PubMed - indexed for MEDLINE]
2004
Lacombe P, Mathews PM, Schmidt SD, Breidert T, Heneka MT, Landreth GE,
Feinstein DL, Galea E.
Effect of anti-inflammatory agents on transforming growth factor beta
over-expressing mouse brains: a model revised.
J Neuroinflammation. 2004 Jul 2;1(1):11.
PMID: 15285804 [PubMed - as supplied by publisher]
Pershadsingh HA, Heneka MT, Saini R, Amin NM, Broeske DJ, Feinstein DL.
Effect of pioglitazone treatment in a patient with secondary multiple sclerosis.
J Neuroinflammation. 2004 Apr 20;1(1):3.
PMID: 15285799 [PubMed - as supplied by publisher]
47: Grommes C, Landreth GE, Heneka MT.
Antineoplastic effects of peroxisome proliferator-activated receptor gamma
agonists.
Lancet Oncol. 2004 Jul;5(7):419-29. Review.
PMID: 15231248 [PubMed - indexed for MEDLINE]
Schneider SW, Ludwig T, Tatenhorst L, Braune S, Oberleithner H, Senner V,
Paulus W.
Glioblastoma cells release factors that disrupt blood-brain barrier features.
Acta Neuropathol. 2004 Mar;107(3):272-6. Epub 2004 Jan 17.
PMID: 14730455 [PubMed - indexed for MEDLINE]
Dehmer T, Heneka MT, Sastre M, Dichgans J, Schulz JB.
Protection by pioglitazone in the MPTP model of Parkinson's disease correlates
with I kappa B alpha induction and block of NF kappa B and iNOS activation.
J Neurochem. 2004 Jan;88(2):494-501.
PMID: 14690537 [PubMed - indexed for MEDLINE]
Schmitz A, Schneider A, Kummer MP, Herzog V.
Endoplasmic reticulum-localized amyloid beta-peptide is degraded in the cytosol
by two distinct degradation pathways.
Traffic. 2004 Feb;5(2):89-101.
PMID: 14690498 [PubMed - indexed for MEDLINE]
Schmidt S, Moric E, Schmidt M, Sastre M, Feinstein DL, Heneka MT.
Anti-inflammatory and antiproliferative actions of PPAR-gamma agonists on T
lymphocytes derived from MS patients.
J Leukoc Biol. 2004 Mar;75(3):478-85. Epub 2003 Dec 4.
PMID: 14657213 [PubMed - indexed for MEDLINE]
2003
Pedraza CE, Baltrons MA, Heneka MT, García A.
Interleukin-1 beta and lipopolysaccharide decrease soluble guanylyl cyclase in
brain cells: NO-independent destabilization of protein and NO-dependent decrease
of mRNA.
J Neuroimmunol. 2003 Nov;144(1-2):80-90.
PMID: 14597101 [PubMed - indexed for MEDLINE]
Sastre M, Dewachter I, Landreth GE, Willson TM, Klockgether T, van Leuven F,
Heneka MT.
Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated
receptor-gamma agonists modulate immunostimulated processing of amyloid precursor
protein through regulation of beta-secretase.
J Neurosci. 2003 Oct 29;23(30):9796-804.
PMID: 14586007 [PubMed - indexed for MEDLINE]
Galea E, Heneka MT, Dello Russo C, Feinstein DL.
Intrinsic regulation of brain inflammatory responses.
Cell Mol Neurobiol. 2003 Oct;23(4-5):625-35. Review.
PMID: 14514020 [PubMed - indexed for MEDLINE]
Klotz L, Sastre M, Kreutz A, Gavrilyuk V, Klockgether T, Feinstein DL, Heneka
MT.
Noradrenaline induces expression of peroxisome proliferator activated receptor
gamma (PPARgamma) in murine primary astrocytes and neurons.
J Neurochem. 2003 Aug;86(4):907-16.
PMID: 12887689 [PubMed - indexed for MEDLINE]
Harzheim M, Altenschmidt M, Heneka MT, Schröder R, Klockgether T, Schmidt S.
IFN-beta1a (Rebif) modifies the expression of microfilament-associated cell-cell
contacts in C6 glioma cells.
J Interferon Cytokine Res. 2003 Feb;23(2):83-9.
PMID: 12744773 [PubMed - indexed for MEDLINE]
Heneka MT, Gavrilyuk V, Landreth GE, O'Banion MK, Weinberg G, Feinstein DL.
Noradrenergic depletion increases inflammatory responses in brain: effects on
IkappaB and HSP70 expression.
J Neurochem. 2003 Apr;85(2):387-98.
PMID: 12675915 [PubMed - indexed for MEDLINE]
Dziewas R, Freund M, Ludemann P, Müller M, Ritter M, Droste DW, Stogbauer F
Treatment options in vertebrobasilar dolichoectasia--case report and review of the literature
Eur Neurol 2003, 49:245-247
Müller M, Leonhard C, Wacker K, Ringelstein EB, Okabe M, Hickey WF, Kiefer R
Macrophage response to peripheral nerve injury: the quantitative contribution of resident and hematogenous macrophages
Lab Invest 2003, 83:175-185
Schilling M, Besselmann M, Leonhard C, Müller M, Ringelstein EB, Kiefer R
Microglial activation precedes and predominates over macrophage infiltration in transient focal cerebral ischemia: a study in green fluorescent protein transgenic bone marrow chimeric mice
Exp Neurol 2003, 183:25-33
Maurer M, Müller M, Kobsar I, Leonhard C, Martini R, Kiefer R
Origin of pathogenic macrophages and endoneurial fibroblast-like cells in an animal model of inherited neuropathy
Mol Cell Neurosci 2003, 23:351-359
2002
Terwel D, Dewachter I, Van Leuven F.
Axonal transport, tau protein, and neurodegeneration in Alzheimer's disease.
Neuromolecular Med. 2002;2(2):151-65. Review.
PMID: 12428809 [PubMed - indexed for MEDLINE]
Spittaels K, Van den Haute C, Van Dorpe J, Terwel D, Vandezande K, Lasrado R,
Bruynseels K, Irizarry M, Verhoye M, Van Lint J, Vandenheede JR, Ashton D,
Mercken M, Loos R, Hyman B, Van der Linden A, Geerts H, Van Leuven F.
Neonatal neuronal overexpression of glycogen synthase kinase-3 beta reduces brain
size in transgenic mice.
Neuroscience. 2002;113(4):797-808.
PMID: 12182887 [PubMed - indexed for MEDLINE]
Feinstein DL, Heneka MT, Gavrilyuk V, Dello Russo C, Weinberg G, Galea E.
Noradrenergic regulation of inflammatory gene expression in brain.
Neurochem Int. 2002 Nov;41(5):357-65. Review.
PMID: 12176079 [PubMed - indexed for MEDLINE]
Breidert T, Callebert J, Heneka MT, Landreth G, Launay JM, Hirsch EC.
Protective action of the peroxisome proliferator-activated receptor-gamma agonist
pioglitazone in a mouse model of Parkinson's disease.
J Neurochem. 2002 Aug;82(3):615-24.
PMID: 12153485 [PubMed - indexed for MEDLINE]
Baltrons MA, Pedraza CE, Heneka MT, García A.
Beta-amyloid peptides decrease soluble guanylyl cyclase expression in astroglial
cells.
Neurobiol Dis. 2002 Jul;10(2):139-49.
PMID: 12127152 [PubMed - indexed for MEDLINE]
Feinstein DL, Galea E, Gavrilyuk V, Brosnan CF, Whitacre CC,
Dumitrescu-Ozimek L, Landreth GE, Pershadsingh HA, Weinberg G, Heneka MT.
Peroxisome proliferator-activated receptor-gamma agonists prevent experimental
autoimmune encephalomyelitis.
Ann Neurol. 2002 Jun;51(6):694-702.
PMID: 12112074 [PubMed - indexed for MEDLINE]
Zander T, Kraus JA, Grommes C, Schlegel U, Feinstein D, Klockgether T,
Landreth G, Koenigsknecht J, Heneka MT.
Induction of apoptosis in human and rat glioma by agonists of the nuclear
receptor PPARgamma.
J Neurochem. 2002 Jun;81(5):1052-60.
PMID: 12065618 [PubMed - indexed for MEDLINE]
Gavrilyuk V, Dello Russo C, Heneka MT, Pelligrino D, Weinberg G, Feinstein
DL.
Norepinephrine increases I kappa B alpha expression in astrocytes.
J Biol Chem. 2002 Aug 16;277(33):29662-8. Epub 2002 Jun 5.
PMID: 12050158 [PubMed - indexed for MEDLINE]
Heneka MT, Galea E, Gavriluyk V, Dumitrescu-Ozimek L, Daeschner J, O'Banion
MK, Weinberg G, Klockgether T, Feinstein DL.
Noradrenergic depletion potentiates beta -amyloid-induced cortical inflammation:
implications for Alzheimer's disease.
J Neurosci. 2002 Apr 1;22(7):2434-42.
PMID: 11923407 [PubMed - indexed for MEDLINE]
Murphy P, Sharp A, Shin J, Gavrilyuk V, Dello Russo C, Weinberg G, Sharp FR,
Lu A, Heneka MT, Feinstein DL.
Suppressive effects of ansamycins on inducible nitric oxide synthase expression
and the development of experimental autoimmune encephalomyelitis.
J Neurosci Res. 2002 Feb 15;67(4):461-70.
PMID: 11835313 [PubMed - indexed for MEDLINE]
Leonhard C, Müller M, Hickey WF, Ringelstein EB, Kiefer R
Lesion response of long-term and recently immigrated resident endoneurial macrophages in peripheral nerve explant cultures from bone marrow chimeric mice
Eur J Neurosci 2002, 16:1654-1660
2001
Landreth GE, Heneka MT.
Anti-inflammatory actions of peroxisome proliferator-activated receptor gamma
agonists in Alzheimer's disease.
Neurobiol Aging. 2001 Nov-Dec;22(6):937-44. Review.
PMID: 11755002 [PubMed - indexed for MEDLINE]
Müller M, Wacker K, Ringelstein EB, Hickey WF, Imai Y, Kiefer R
Rapid response of identified resident endoneurial macrophages to nerve injury
Am J Pathol 2001, 159:2187-2197.
Heneka MT, Wiesinger H, Dumitrescu-Ozimek L, Riederer P, Feinstein DL,
Klockgether T.
Neuronal and glial coexpression of argininosuccinate synthetase and inducible
nitric oxide synthase in Alzheimer disease.
J Neuropathol Exp Neurol. 2001 Sep;60(9):906-16.
PMID: 11556547 [PubMed - indexed for MEDLINE]
Mulder M, Blokland A, van den Berg DJ, Schulten H, Bakker AH, Terwel D, Honig
W, de Kloet ER, Havekes LM, Steinbusch HW, de Lange EC.
Apolipoprotein E protects against neuropathology induced by a high-fat diet and
maintains the integrity of the blood-brain barrier during aging.
Lab Invest. 2001 Jul;81(7):953-60.
PMID: 11454984 [PubMed - indexed for MEDLINE]
Heneka MT, Sharp A, Murphy P, Lyons JA, Dumitrescu L, Feinstein DL.
The heat shock response reduces myelin oligodendrocyte glycoprotein-induced
experimental autoimmune encephalomyelitis in mice.
J Neurochem. 2001 Apr;77(2):568-79.
PMID: 11299319 [PubMed - indexed for MEDLINE]
Heneka MT, Feinstein DL.
Expression and function of inducible nitric oxide synthase in neurons.
J Neuroimmunol. 2001 Mar 1;114(1-2):8-18. Review.
PMID: 11240010 [PubMed - indexed for MEDLINE]
Heneka MT, Landreth GE, Feinstein DL.
Role for peroxisome proliferator-activated receptor-gamma in Alzheimer's disease.
Ann Neurol. 2001 Feb;49(2):276. No abstract available.
PMID: 11220752 [PubMed - indexed for MEDLINE]
2000
Hoffmann J, Twiesselmann C, Kummer MP, Romagnoli P, Herzog V.
A possible role for the Alzheimer amyloid precursor protein in the regulation of
epidermal basal cell proliferation.
Eur J Cell Biol. 2000 Dec;79(12):905-14.
PMID: 11152291 [PubMed - indexed for MEDLINE]
Hitzel C, Kanzler H, König A, Kummer MP, Brix K, Herzog V, Koch N.
Thyroglobulin type-I-like domains in invariant chain fusion proteins mediate
resistance to cathepsin L digestion.
FEBS Lett. 2000 Nov 17;485(1):67-70.
PMID: 11086167 [PubMed - indexed for MEDLINE]
Heneka MT, Klockgether T, Feinstein DL.
Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal
inducible nitric oxide synthase expression and cell death in vivo.
J Neurosci. 2000 Sep 15;20(18):6862-7. Erratum in: J Neurosci 2000 Nov
15;20(22):1a.
PMID: 10995830 [PubMed - indexed for MEDLINE]
Terwel D, Nieland LJ, Schutte B, Reutelingsperger CP, Ramaekers FC,
Steinbusch HW.
S-nitroso-N-acetylpenicillamine and nitroprusside induce apoptosis in a neuronal
cell line by the production of different reactive molecules.
Eur J Pharmacol. 2000 Jul 14;400(1):19-33.
PMID: 10913581 [PubMed - indexed for MEDLINE]
Heneka MT, Sharp A, Klockgether T, Gavrilyuk V, Feinstein DL.
The heat shock response inhibits NF-kappaB activation, nitric oxide synthase type
2 expression, and macrophage/microglial activation in brain.
J Cereb Blood Flow Metab. 2000 May;20(5):800-11.
PMID: 10826530 [PubMed - indexed for MEDLINE]
Müller M, Wacker K, Hickey WF, Ringelstein EB, Kiefer R
Co-Localization of Multiple Antigens and Specific DNA: A Novel Method Using Methyl Methacrylate-Embedded Semithin Serial Sections and Catalyzed Reporter Deposition
Am J Pathol 2000, 157:1829-1838
Heneka MT, Dumitrescu L, Löschmann PA, Wüllner U, Klockgether T.
Temporal, regional, and cell-specific changes of iNOS expression after
intrastriatal microinjection of interferon gamma and bacterial
lipopolysaccharide.
J Chem Neuroanat. 2000 Apr;18(4):167-79.
PMID: 10781735 [PubMed - indexed for MEDLINE]
Kiefer R, Dangond F, Müller M, Toyka KV, Hafler DA, Hartung HP
Enhanced B7 costimulatory molecule expression in inflammatory human sural nerve biopsies
J Neurol Neurosurg Psychiatry 2000, 69:362-368
1999
Heneka MT, Feinstein DL, Galea E, Gleichmann M, Wüllner U, Klockgether T.
Peroxisome proliferator-activated receptor gamma agonists protect cerebellar
granule cells from cytokine-induced apoptotic cell death by inhibition of
inducible nitric oxide synthase.
J Neuroimmunol. 1999 Dec;100(1-2):156-68.
PMID: 10695726 [PubMed - indexed for MEDLINE]
Heneka MT, Schmidlin A, Wiesinger H.
Induction of argininosuccinate synthetase in rat brain glial cells after striatal
microinjection of immunostimulants.
J Cereb Blood Flow Metab. 1999 Aug;19(8):898-907.
PMID: 10458597 [PubMed - indexed for MEDLINE]
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